Thiazolidine derivatives

专利名称：Thiazolidine derivatives发明人：Toda, Masaaki,Ohuchida, Shuichi /

Shinbayashidanchi 19-103, ,Ohno, Hiroyuki

申请号：EP88102243.8申请日：19880216公开号：EP0280956B1公开日：19921021

摘要：A novel thiazolidine derivative of general formula: [wherein R represents agroup of general formula:     G-E-D-B-A- (wherein A represents single bond, alkylenegroup of from 1 to 6 carbon atom(s), alkenylene group of from 2 to 6 carbon atoms, agroup of general formula: or saturated hydrocarbon ring of from 4 to 7 carbon atoms orsingle heterocyclic ring. Y represents alkylene group of from 1 to 4 carbon atom(s) oralkenylene group of from 2 to 4 carbon atoms. B represents single bond or alkylenegroup of from 1 to 6 carbon atom(s). D represents single bond, oxygen atom, carbonylgroup or a group of general formula: R¹ represents hydrogen atom, alkyl group of from1 to 4 carbon atom(s), phenyl group or benzyl group. E represents single bond, alkylenegroup of from 1 to 8 carbon atom(s) or alkylene group of from 1 to 8 carbon atom(s)substituted by phenyl group or benzyl group. G represents carbocyclic or heterocyclicring unsubstituted or substituted by from one to three of alkyl group of from 1 to 6carbon atom(s), alkoxy group of from 1 to 6 carbon atom(s), halogen atom,

trifluoromethyl group or nitro group.) With the proviso that, A and B do not representmono-bonds at the same time.] possess inhibitory activity on prolyl endopeptidase, andtherefore be useful for treating and/or preventing agent for amnesia.

申请人：ONO PHARMACEUTICAL CO., LTD.

地址：NO. 14, DOSHOMACHI 2-CHOME HIGASHI-KU; OSAKA-SHI OSAKA

代理机构：Henkel, Feiler, Hänzel & Partner

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