Compositions and methods for producing enhanced an

专利名称：Compositions and methods for producing

enhanced antibodies

发明人：William D. Huse,Scott M. Glaser申请号：US11439071申请日：20060522

公开号：US20060204492A1公开日：20060914

摘要：The invention provides a Vitaxin antibody and a LM609 grafted antibodyexhibiting selective binding affinity to αβ. The Vitaxin antibody consists of at least oneVitaxin heavy chain polypeptide and at least one Vitaxin light chain polypeptide orfunctional fragments thereof. Also provided are the Vitaxin heavy and light chainpolypeptides and functional fragments. The LM609 grafted antibody consists of at leastone CDR grafted heavy chain polypeptide and at least one CDR grafted light chainpolypeptide or functional fragment thereof. The invention additionally provides a highaffinity LM609 grafted antibody comprising one or more CDRs having at least one aminoacid substitution, where the αβbinding activity of the high affinity LM609 grafted antibodyis enhanced. Nucleic acids encoding Vitaxin and LM609 grafted heavy and light chains aswell as nucleic acids encoding the parental non-human antibody LM609 are additionallyprovided. Functional fragments of such encoding nucleic acids are similarly provided. Theinvention also provides a method of inhibiting a function of αβ. The method consists ofcontacting αβwith Vitaxin or a LM609 grafted antibody or functional fragments thereofunder conditions which allow binding to αβ. Finally, the invention provides for a methodof treating an αβ-mediated disease. The method consists of administering an effective

amount of Vitaxin or a LM609 grafted antibody or functional fragment thereof underconditions which allow binding to αβ.

申请人：William D. Huse,Scott M. Glaser

地址：Del Mar CA US,San Diego CA US

国籍：US,US

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