INHIBITION OF MULTIPLE CELL ACTIVATION PATHWAYS

专利名称：INHIBITION OF MULTIPLE CELL

ACTIVATION PATHWAYS

发明人：AGREZ, MICHAEL, VALENTINE,DORAHY,

DOUGLAS

申请号：EP10743341申请日：20100223公开号：EP2398484A4公开日：20130710

摘要：There is provided a method for inhibiting growth and/or proliferation of acancer cell. The method comprises treating a cancer cell with an effective amount of apolypeptide providing a cytoplasmic binding domain of a β integrin subunit for binding ofERK2 to inhibit at least one protein kinase, other than a MAP kinase, in a cell activationpathway of the cancer cell. The protein kinases inhibited by the polypeptide may beselected from the group consisting of c-Raf, MEK 1 and kinases in the Src, PI3K, PKB/AKTand PKC families. Methods for the prophylaxis and treatment of cancer are also provided.

申请人：INTER-K PTY LIMITED

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