CELL-TARGETING NANOPARTICLES COMPRISING POLYNUCLEO

专利名称：CELL-TARGETING NANOPARTICLES

COMPRISING POLYNUCLEOTIDE AGENTSAND USES THEREOF

发明人：Dan PEER申请号：US15402444申请日：20170110

公开号：US20170143641A1公开日：20170525

摘要：A method of generating a particle is disclosed, the particle being for delivery ofa polynucleotide to a target cell. The method comprises (a) contacting the

polynucleotide with a composition comprising cationic molecules, wherein the cationicmolecules condense the polynucleotide by electrostatic interactions to generate acomplex, wherein the cationic molecules are not comprised in a liposome; and (b)covalently binding the complex to a targeting moiety at a pH equal to or below about4.5, thereby generating the particle for delivery of the polynucleotide agent to thetarget cell. Use of the particles and compositions comprising same are also disclosed.

申请人：RAMOT AT TEL-AVIV UNIVERSITY LTD.

地址：Tel Aviv IL

国籍：IL

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