Methods and means for treatment of osteoarthritis

专利名称：Methods and means for treatment of

osteoarthritis

发明人：Reginald Christophe Xavier Brys,Luc

Nelles,Nick Ernest Rene

Vandeghinste,Blandine Mille-Baker,MichelaAngela Tessari

申请号：US13262634申请日：20100401公开号：US08663930B2公开日：20140304

摘要：The invention relates to the field of medicinal research, cartilage physiology anddiseases involving the degeneration of cartilage tissue. More specifically, the inventionrelates to methods and means for identifying compounds that inhibit catabolic processesin chondrocytes and that decrease the degradation of cartilage and/or ECM. Theinvention also relates to the compounds that are useful in the treatment of

osteoarthritis. The invention also relates to targets, the modulation of which results in adecrease in the degradation of ECM and/or cartilage and decrease inflammation. Inaddition, the invention relates to compositions and methods for the use thereof intreating conditions that are characterized by the degradation of ECM and/or cartilageand inflammation.

申请人：Reginald Christophe Xavier Brys,Luc Nelles,Nick Ernest ReneVandeghinste,Blandine Mille-Baker,Michela Angela Tessari

地址：Mechelen BE,Mechelen BE,Mechelen BE,Leiden NL,Leiden NL

国籍：BE,BE,BE,NL,NL

代理机构：Klauber & Jackson LLC

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